Endocrine Abstracts

Introduction: Literature has already described some cases of hypophysitis related to acute respiratory syndrome coronavirus 2 (SARS-Cov2). The pituitary is indeed target for the virus due to the angiotensin-converting-enzyme-2 expression. Hypophysitis patients present with mass effect and pituitary dysfunction related symptoms. ACTH and TSH deficiencies are the most reported, along with central diabetes insipidus (CDI). The best way to manage these hypophysitis is still undefi...

Genetic discoveries improved the understanding of the etiology and pathogenesis of several diseases, including acromegaly. Germline mutations involving AIP, MEN1, CDKN1B, GPR101, PRKAR1A, and GNAS genes have been described in GH-secreting PitNETs, but realistically many genetic alterations have not been identified yet. Nowadays, RET mutations have not been reported in acromegaly, if not exclusively in the context of a multiple endocrine neoplasia (MEN). A 48-year-old patient w...

Background: Pituitary metastases are rare findings and account for 1% of surgically treated pituitary lesions. Despite the low incidence, given the frequent compression exerted on surrounding structures, pituitary metastases can present with major symptoms such as headache, visual disturbances and visual field. Ultimately, damage to the pituitary gland may be associated with electrolyte disturbances.Clinical case: A 57-year-old male patient was admitted ...